Cyclin D linked to breast cancer transition
This article was originally published in Clinica
Executive Summary
Cyclin D regulation may define a major transition from a benign state to commitment to carcinoma in human breast cancer. Researchers at the US National Cancer Institutes in Bethesda, Maryland undertook comparative in situ hybridisation studies on 94 breast biopsy lesions of four different types: those conferring no or slightly increased risk for breast cancer; atypical ductal hyperplasias (ADHs); ductal carcinomas in situ (DCIS), ranging from noncomedo forms to comedo forms; and invasive breast cancers. (Nature Medicine, December.)