Link between A2M gene and Alzheimer's disputed:
This article was originally published in Clinica
Executive Summary
Polymorphisms of the alpha-2-macroglobulin (A2M) gene do not appear to be associated with late-onset Alzheimer's disease, contrary to some reports, claims a team of Dutch researchers in the September issue of Neurology. Researchers at the Erasmus Medical Centre in Rotterdam studied two A2M polymorphisms in 344 patients with late-onset disease and 242 controls. There was no observable genotypic or allelic association with late-onset disease, although one of the polymorphisms was significantly less common in patients of Asian origin.