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Clinical Update (11/2007)

Executive Summary

Brief summaries of recent clinical developments in the device industry, including a new electronic wound monitor, a tiny radio with medical potential, cutting-edge diabetes research, and advanced imaging for cancer detection and treatment.

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Cizzle Biotechnology Ltd.

Cizzle Biotechnology is focusing on the gene Ciz1 and its variant, found in small-cell lung cancer. The trigger for the start-up's formation was the finding that cells require Ciz1 to grow, and that variant forms could be used for selective targeting of cancer cells, especially small-cell lung cancer. The company's founders have shown that blocking the disrupted form of Ciz1, using a small interfering RNA (siRNA) targeted to the variant, prevented cell proliferation and growth in vitro. The specificity of the Ciz1 variant also gives it potential as a biomarker for early detection of lung cancer.

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