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Dimerix Bioscience Pty. Ltd.

Latest From Dimerix Bioscience Pty. Ltd.

Dimerix CEO Explains Company's Different Drug Combo R&D Strategy

Global director of content for Informa Pharma Intelligence, Mike Ward, talks to Kathy Harrison, CEO of Australian biotech Dimerix, about the company's unusual business model.

StartUps and SMEs Business Strategies

Start-Up Previews (02/2009)

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Building the Next-Generation of GPCR-Targeting Drugs," features profiles of Catena Pharmaceuticals, Dimerix Bioscience, Heptares Therapeutics and Trevena. Plus these Start-Ups Across Health Care: Carmat, Glycan Biosciences, Itero and MaRVis Technologies.

Dimerix Bioscience Pty. Ltd.

Dimerix Bioscience is using its proprietary assay technology to identify GPCRs that act in pairs to form GPCR heterodimers. These receptor pairs bind ligands differently, and trigger alternate signaling pathways to stand-alone GPCR monomers, which have provided the model for most drug discovery in this area to date. This understanding, gained over the last decade or so, that some GPCRs act in groups of two or more, raises the possibility of using several types of ligands to elicit precisely the response pattern required from the individual GPCRs within the pair. Thus for example if one GPCR leads to a positive effect and the other to a negative one, scientists might combine an agonist to generate the positive effect, and an antagonist to block the negative response.

Building the Next Generation of GPCR-Targeting Drugs

One-third of marketed drugs hit G-protein coupled receptors, a group of cell-membrane bound receptors that are involved in almost every possible biological system. Drugs targeting GPCRs span most therapy areas, specialist or primary care, and may be small molecules, peptides, or large proteins. Despite their ubiquity, there's plenty of untapped potential too. Small wonder that start-ups continue to appear in this field, each with its own approach to improving existing drugs and finding new ones. We profile four in this issue.
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Company Information

  • Industry
  • Biotechnology
    • Drug Discovery Tools
  • Pharmaceuticals
  • Therapeutic Areas
  • Non-Specific
  • Alias(es)
  • Ownership
  • Private
  • Headquarters
  • Worldwide
    • Australia
  • Parent & Subsidiaries
  • Dimerix Bioscience Pty. Ltd.
  • Senior Management
  • James Williams, PhD, CEO
  • Contact Info
  • Dimerix Bioscience Pty. Ltd.
    Phone: (61) 409 050 519
    W. Australian Inst. for Medical Research
    Hospital Ave.
    Nedlands, WA 6009