Replicative senescence in atherosclerosis:
This article was originally published in Clinica
Executive Summary
The cell ageing process - replicative senescence - may play an important role in the development of clinical vascular disease, as an accumulation of senescent endothelial cells in the arteries contributes to atherosclerotic plaque formation and thrombosis. These conclusions (Proceedings of the National Academy of Sciences, November 21st), by a team from Geron (US), were drawn following the observation that chromosomal telomere length can be used as a marker of human vascular ageing, and telomere loss in vivo is greater in cells from tissues implicated in atherosclerosis (eg arteries), than in cells not involved (eg from veins).
You may also be interested in...
New EU Approvals
The Pink Sheet's list of EU centralized approvals of new active substances has been updated to add two new products, including Ryzneuta, Evive Biotechnology's treatment for chemotherapy-induced neutropenia.
Pair Of Deaths Linked To Recalled Vyaire Medical Respiratory Devices
The US FDA has labelled a recall of more than 6 million Airlife respiratory support devices class I. The recall covers devices manufactured in 2017 or earlier that can fail to provide adequate ventilation.
Over The Counter 2 Apr 2024: Analyzing The Spin-Out Trend In Consumer Health, With HBW’s Malcolm Spicer And Tom Gallen
In this episode, HBW Insight’s Europe and US editors bring their expertise to bear on the current the trend towards standalone OTC companies in global consumer health. We look at four major players: Haleon, which separated from GSK almost two years ago; Kenvue, soon to celebrate its first anniversary as a new company; Sanofi Consumer Healthcare, which is poised to split from its pharma parent; and Bayer, which has decided to buck the trend, holding on to its consumer health division. We discuss some of the advantages of becoming a standalone company, for example in leaning into a wider concept of self-care.