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Gene therapy reverses heart disease in mice:

This article was originally published in Clinica

Executive Summary

A French team has reported that a new gene therapy involving the transplantation of the human version of the apolipoprotein E gene (apoE) into mice has led to a complete regression of fatty plaque deposits in the animals' arteries. Mice that received the apoE gene also had significant reductions in total cholesterol and triglycerides and an increase in levels of beneficial high-density lipoprotein cholesterol, said researchers from Gencell in Vitry/Seine, France, a division of Rhone-Poulenc. The findings appear in the February issue of Arteriosclerosis, Thrombosis and Vascular Biology.

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