Susceptibility may be the key, says ViroLogic:
This article was originally published in Clinica
After years spent studying HIV drug resistance, ViroLogic now believes that the opposite phenomenon, viral hypersusceptibility, may offer a way to improve treatment for HIV-infected patients. In a retrospective study of 30 treatment-experienced patients published in AIDS (June 15th), ViroLogic researchers found that the reduction in viral load following treatment with non-nucleoside reverse transcriptase inhibitors (NNRTIs) was 20 times higher in patients with virus that was hypersusceptible to NNRTIs, and no resistance-related mutations, than in those with virus showing normal sensitivity to the drugs. Viral sensitivity was determined using the South San Francisco, California company's PhenoSense HIV drug resistance assay.