Plasminogen key to test for CJD (Creutzfeldt-Jakob disease):
This article was originally published in Clinica
A new approach to the diagnosis of transmissible spongiform encephalopathies such as Creutzfeld-Jakob disease may be possible thanks to research into how the abnormal prion protein enters the nervous system. Prof Adriano Aguzzi told the World Congress of Neurology in Switzerland last month that the protein appears to bind to plasminogen before being taken up by the lymphatic system, from were it travels to the brain. The ability of plasminogen to differentiate between normal and abnormal protein could be harnessed as the basis of a sensitive diagnostic test, he believes.
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