Medtech Insight is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction
UsernamePublicRestriction

Genes may predict toxicity to leukaemia therapy:

This article was originally published in Clinica

Executive Summary

US researchers have identified genetic variations - polymorphisms - that could cause children with acute lymphoblastic leukaemia (ALL) to react badly to some chemotherapy drugs. The findings could help patients avoid harmful and potentially life-threatening side-effects of these drugs, and potentially allow doctors to individualise ALL chemotherapy according to each patient. "Such individualised therapy would eliminate the time-consuming trial-and-error approach to finding the right dose for a patient," said researcher Mary Relling, of St Jude's Children's Research Hospital in Memphis, Tennessee. The researchers identified 16 polymorphisms within genes that are known to affect the influence the pharmacodynamics of the drug in the body. The findings are published in the May 15 issue of Blood.

You may also be interested in...



Novartis Faces Another Challenge To Entresto In India

More patent-related turbulence appears ahead for Novartis’s sacubitril/valsartan combination in India, with Torrent emerging as the new challenger. The companies are engaged in a legal battle and the Indian firm is also seeking a revocation of the patent on the star heart failure treatment.

Cosmetic And Personal Care Trademark Review 24 November, 2020

Personal care and cosmetic product trademark filings compiled from the Official Gazette of the US Patent and Trademark Office, Class 3.

CBD Health Benefits More Attractive To Women? FDA Prioritizes Research Into Utero Effects

Among the largest gaps in safety data is non-clinical research on CBD use's effect on developing fetus and adolescent brain, in utero/lactational exposure, reproductive toxicity and the potential for a latency period before toxicity, says FDA  neuroscientist Andrew Shen.

Topics

UsernamePublicRestriction

Register

OM001644

Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel