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Sensimed AG

This article was originally published in Start Up

Executive Summary

In the field of glaucoma, there are a lot of unknowns because it hasn't previously been feasible to continuously monitor intraocular pressure. Sensimed was formed to do just that. The young company is developing a sensor that would provide 24-hours worth of intraocular pressure data as an alternative to the point-by-point measurement systems available today. The company likens its device to the Holter monitor in cardiovascular disease-a device that can yield a comprehensive set of diagnostic data as a patient goes about his or her daily life.

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In Glaucoma, Devices Go Eye-to-Eye with Drugs

Glaucoma is of serious interest to VCs and strategic investors because of its sheer size; the disease affects 3 million people, most of them managed by drugs. Glaucoma drugs have created a $4 billion market, but have several problems, the greatest of which is non-compliance. Glaukos and other device companies aim to introduce devices that are safe and efficacious enough to compete directly with drugs, rather than standing in as an alternative to today's glaucoma surgeries reserved for end-stage patients. Glaukos recently marked a first of its kind victory; with a tiny implantable ophthalmic stent, Glaukos emerged from a PMA clinical trial that convinced an FDA panel of the benefit-to-risk ratio of its approach when used as a first-line therapy in a select group.

In Glaucoma, Devices Go Eye-to-Eye with Drugs

Glaucoma is of serious interest to VCs and strategic investors because of its sheer size; the disease affects 3 million people, most of them managed by drugs. Glaucoma drugs have created a $4 billion market, but have several problems, the greatest of which is non-compliance. Glaukos and other device companies aim to introduce devices that are safe and efficacious enough to compete directly with drugs, rather than standing in as an alternative to today's glaucoma surgeries reserved for end-stage patients. Glaukos recently marked a first of its kind victory; with a tiny implantable ophthalmic stent, Glaukos emerged from a PMA clinical trial that convinced an FDA panel of the benefit-to-risk ratio of its approach when used as a first-line therapy in a select group.

Glaucoma Start-Ups Reach Critical Mass

Having validated high intraocular pressure as a certain target for intervention, the Ocular Hypertension Treatment Study spurred on a new wave of innovation in medical devices for glaucoma. Numerous start-ups formed five or six years ago are now beginning to run their devices through clinical trials. Indeed, the field seems to have gained a critical mass of attention. Start-Up has identified more than a dozen emerging device companies treating glaucoma, and the disease remains a target for development programs and acquisitions on the pharmaceutical side as well.

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