Medtech Insight is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By



This article was originally published in The Gray Sheet

Executive Summary

GENETICALLY ENHANCED CARDIOVASCULAR IMPLANT PROJECTS WOULD BE FUNDED under a proposed request for applications (RFA) approved by a National Heart, Lung and Blood Institute advisory council at a May 27-28 meeting. NHLBI hopes the funding initiative will lead to the development of implantable cardiovascular devices lined with genetically modified cells. Possible types of genetically modified cardiovascular implants include devices that would secrete substances locally to enhance the biocompatibility of the product. Most conventional cardiovascular devices, such as artificial hearts, ventricular assist devices, valves and stents, have a certain degree of biocompatibility problems. Cells capable of controlling or preventing thrombosis and intimal hyperplasia could help address that issue. In addition to local benefits, genetically modified implants could be used as "'organoids' (hybrid organs composed of a biomaterial lattice coated with secretory cells) which would function as a source for chronic systemic delivery of agents with desirable cardiovascular actions," NHLBI says. While the feasibility of developing an organoid for systemic delivery of modified cells already has been established, research is needed "to determine the function and control of such an organoid over prolonged time," according to the institute. The five-year, $4.1 mil. initiative would fund three to four new projects. First-year funding is set at $750,000 in FY 1994. Specific areas of research suggested by NHLBI include: the study of genetic modification of endothelial or other cells for production of recombinant proteins with desired therapeutic effects; investigation of the long-term function of genetically modified cells seeded on the implants; and study of the parameters which affect the functions of organoids for cardiovascular applications.

You may also be interested in...

Novartis Logs Into India With Digital Innovation Hub

Novartis’s first digital innovation hub in Asia is launched in India, where the Swiss company hopes to ally with partners to deliver digital solutions for patients at scale.

Rx List Price Inflation Penalty Endorsed By US HHS Secretary

Senate Finance Committee’s approach to penalize companies for raising WAC list prices is not a ‘price control,’ but a reasonable approach to change the incentives that distort pricing in the supply chain, US HHS Secretary Alex Azar says.

Generics Approvals Will Decline, US FDA Predicts, But Supplement Work May Grow

With the pre-GDUFA backlog largely acted upon, the FDA expects ANDA approvals to decrease, but supplement actions to increase in FY 2020 and FY 2021.




Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts